S Ketamine delivered intranasally via a spray bottle. Each spray typically delivers a measured 30mg dose directly into the nasal mucosa for rapid absorption into the bloodstream.
What is S-Type (S-Ketamine or Esketamine)?
- Ketamine exists in two mirror-image forms: S-ketamine and R-ketamine.
- S-ketamine (esketamine) is considered the more potent and rapid-acting isomer in terms of its antidepressant effects.
- It’s the active ingredient in the FDA-approved nasal spray Spravato (by Janssen).
Benefits of S-Ketamine Nasal Sprays:
1. Rapid Antidepressant Effect
- Works in hours to days, much faster than traditional antidepressants, which can take weeks.
- Especially helpful for treatment-resistant depression (TRD).
2. Reduces Suicidal Thoughts
- Shown to quickly reduce suicidal ideation in patients with major depressive disorder.
3. Low Dose = Reduced Dissociation
- Nasal sprays allow lower, controlled doses, reducing side effects like disorientation or hallucinations compared to IV ketamine.
4. Convenient & Non-Invasive
- No needles or IVs required — making it easier for some patients to tolerate.
5. Neuroplasticity Boost
- Ketamine increases glutamate activity and brain-derived neurotrophic factor (BDNF), which supports the brain’s ability to adapt and rewire.
*Risks & Considerations*
- Should be used under supervision (often in clinics due to potential for abuse).
- Side effects: dissociation, dizziness, nausea, increased blood pressure.
- Not a first-line treatment—usually prescribed after multiple antidepressants have failed.
- Not for recreational use—30mg is a lower dose that can still cause cognitive or physical impairment if misused
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